Calculates repeatability statistics for replicate measurements performed under identical conditions (same operator, instrument, short time interval).
Arguments
- data
A data frame containing replicate measurements.
- response_col
Name of the column containing the response values.
- group_col
Optional name of a grouping column (e.g., concentration level). If provided, repeatability is calculated within each group.
- conf_level
Confidence level for intervals. Default is 0.95.
Value
A measure_precision object containing:
mean: Mean of the replicatessd: Standard deviationcv: Coefficient of variation (%)n: Number of replicatesse: Standard errorci_lower,ci_upper: Confidence interval for the mean
Details
Repeatability represents the precision of a method under constant conditions over a short time interval. It is typically assessed using at least 6 replicates of a sample at each concentration level of interest.
The coefficient of variation (CV) is reported as a percentage:
CV = 100 * SD / mean
Examples
# Simple repeatability from replicate measurements
data <- data.frame(
sample_id = rep("QC1", 10),
concentration = rnorm(10, mean = 100, sd = 2)
)
measure_repeatability(data, "concentration")
#> measure_precision: repeatability
#> ────────────────────────────────────────────────────────────────────────────────
#> n = 10
#> Mean = 99.38
#> SD = 1.9
#> CV = 1.9 %
#> 95% CI: [98.02, 100.7]
# Repeatability at multiple concentration levels
data <- data.frame(
level = rep(c("low", "mid", "high"), each = 6),
concentration = c(
rnorm(6, 10, 0.5),
rnorm(6, 50, 2),
rnorm(6, 100, 4)
)
)
measure_repeatability(data, "concentration", group_col = "level")
#> measure_precision: repeatability
#> ────────────────────────────────────────────────────────────────────────────────
#>
#> Group: low
#> n = 6
#> Mean = 10.19
#> SD = 0.2589
#> CV = 2.5 %
#> 95% CI: [9.915, 10.46]
#>
#> Group: mid
#> n = 6
#> Mean = 49.33
#> SD = 2.66
#> CV = 5.4 %
#> 95% CI: [46.54, 52.12]
#>
#> Group: high
#> n = 6
#> Mean = 101.5
#> SD = 4.006
#> CV = 3.9 %
#> 95% CI: [97.32, 105.7]